Multiple sclerosis (MS) affects cognition in the majority of patients. A major aspect of the disease is brain volume loss (BVL),\npresent in all phases and types (relapsing and progressive) of the disease and linked to both motor and cognitive disabilities.\nDue to the lack of effective pharmacological treatments for cognition, cognitive rehabilitation and other nonpharmacological\ninterventions such as repetitive transcranial magnetic stimulation (rTMS) have recently emerged and their potential role in\nfunctional connectivity is studied. With recently developed advanced neuroimaging and neurophysiological techniques, changes\nrelated to alterations of the brain�s functional connectivity can be detected. In this overview, we focus on the brain�s functional\nreorganization in MS, theoretical and practical aspects of rTMS utilization in humans, and its potential therapeutic role in\ntreating cognitively impaired MS patients.
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